California gold rush, late 1800's: A gun slinging bounty hunter (Mortimer) travels deep into the mountains to find a deadly Apache warrior (Brother Wolf) who is wanted by the law. Along the way he passes through a gold mining Town. The miners help direct Mortimer to the Apache and send him on his way. Mortimer enters the forest and begins to track the Apache. Back in town, the miners un-earth an ancient meteor. They use their pick axes to crack it open. A section of the meteor splits apart and spores explode out of it. The spore surround and infect the entire population of the mining camp. They are transformed into ravenous mutants. After a vicious battle against the Apache warrior, Mortimer exits the forest with his prisoner in shackles. They hike back to the mining town to find them selves surrounded by a horde of blood thirsty mutants. Now Mortimer the gun slinger and Brother Wolf the Warrior must join together to survive the mutant hordes. What ensues is a bloodbath of horror for the Dead and the Damned.
公仔杀人事件经媒体报道后，引发制作“楚其”的玩具公司对市场前景的担忧，玩具公司将楚其的残骸收回并加以修复，试图向股东证明杀人玩具不过是谣言一场，然而在修复完成时，楚其随即复活，它引发混乱，并最终逃脱。另一方面，安迪（艾力克斯·文森特 Alex Vincent 饰）和母亲分别接受心理治疗，一对好心夫妇暂时照顾安迪。根据灵魂转移的符咒要求，楚其如果要避免与公仔一同人格化的命运，就必须寄宿到第一个知晓它秘密的人——也就是安迪身上，楚其剩下的时间已经不多，它再度找到安迪准备侵占其身体。安迪为了躲避找上门的楚其，用尽办法得到的却是周围大人的不理解与训斥，和安迪一起被收养的少女凯莉也卷入了这场公仔夺取安迪身体的非常事件……
年轻人本（杰瑞米·艾文 Jeremy Irvine 饰）固守着世代经营的向导和搜救工作，为此只能与青梅竹马的女朋友莱娜两地相隔，独自留在蛮荒的旷野沙漠地带。某天，早已功成名就的商界人士约翰·麦迪克（迈克尔·道格拉斯 Michael Douglas 饰）开着美国仅此一辆的SUV来到小镇，他热爱狩猎，为了猎杀大角羊而整装完备。约翰坚信钱可以打通一切，因此花钱收买了警长和本，取得了猎杀大角羊的机会。苍茫旷野，杳无人烟，本引导着约翰走入炎热的矿业腹地。谁知情况急转直下，踌躇满志的约翰不小心射杀了一名当地人，这位善于衡量利益权重的男人为求自保，不惜将约翰拉入这个血腥的泥潭。
与世隔绝的死亡之地，两个男人展开了实力悬殊的较量……
